Views Read Edit View history. A family history of bleeding helps in narrowing the diagnosis. In the patient with liver disease who also has a large spleen, the use of platelet concentrates to halt a bleeding episode may be effective even if the platelet count does not significantly rise. Importantly, platelet transfusions are highly contraindicated in HIT patients, as this can promote the development of large thrombi that result in amputation, stroke, and venous thrombosis, all of which can produce death. Crit Care.
Coagulopathy may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation factors. The type and location of past bleeding is informative.